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Structure paper

TitleProtein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design.
Journal, issue, pagesStructure, Vol. 32, Page 1040-1048.e3, Year 2024
Publish dateNov 30, 2023 (structure data deposition date)
AuthorsMukherjee, M. / Day, P.J. / Laverty, D. / Bueren-Calabuig, J.A. / Woodhead, A.J. / Griffiths-Jones, C. / Hiscock, S. / East, C. / Boyd, S. / O'Reilly, M.
External linksStructure / PubMed:38870939
MethodsX-ray diffraction
Resolution1.51 - 2.78 Å
Structure data

PDB-8r99:
A soakable crystal form of human CDK7 in complex with AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

PDB-8r9a:
A soakable crystal form of human CDK7 in complex with AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 1.71 Å

PDB-8r9b:
A soakable crystal form of human CDK7 in complex with AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

PDB-8r9o:
A soakable crystal form of human CDK7 in complex with AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

PDB-8r9s:
A soakable crystal form of human CDK7 in complex with AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 2.78 Å

PDB-8r9u:
A soakable crystal form of human CDK7 in complex with AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 1.937 Å

PDB-8ru8:
A crystal form of a human CDK2-CDK7 chimera
Method: X-RAY DIFFRACTION / Resolution: 1.51 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-I74:
(3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol

ChemComp-GOL:
GLYCEROL


ChemComp, No image

ChemComp-YN3:
Unknown entry

ChemComp-PE3:
3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL


ChemComp, No image

ChemComp-YPK:
Unknown entry


ChemComp, No image

ChemComp-YNK:
Unknown entry

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / serine-threonine kinase / phosphorylation / cell cycle progression / ATP binding / SIGNALING PROTEIN / cyclin dependent kinase 7 / serine/threonine kinase / cell cycle kinase

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