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Structure paper

TitleTargeted protein degradation systems to enhance Wnt signaling.
Journal, issue, pagesElife, Vol. 13, Year 2024
Publish dateAug 10, 2023 (structure data deposition date)
AuthorsSampathkumar, P. / Jung, H. / Chen, H. / Zhang, Z. / Suen, N. / Yang, Y. / Huang, Z. / Lopez, T. / Benisch, R. / Lee, S.J. ...Sampathkumar, P. / Jung, H. / Chen, H. / Zhang, Z. / Suen, N. / Yang, Y. / Huang, Z. / Lopez, T. / Benisch, R. / Lee, S.J. / Ye, J. / Yeh, W.C. / Li, Y.
External linksElife / PubMed:38847394
MethodsX-ray diffraction
Resolution1.7 - 1.9 Å
Structure data

PDB-8ts0:
Crystal Structure of human ASGR1 CRD (Carbohydrate Recognition Domain) bound to 8M24 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8urf:
Crystal Structure of human ASGR2 CRD (Carbohydrate Recognition Domain) bound to 8G8 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsSUGAR BINDING PROTEIN/IMMUNE SYSTEM / ASGR / ASGPR / 8M24 / Endocytosis / SUGAR BINDING PROTEIN / SUGAR BINDING PROTEIN-IMMUNE SYSTEM complex / ASGR2 / ASGR1 / Fab / 8G8 / AbTAC / LYTAC / Antibody

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