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Structure paper

TitleHuman SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.
Journal, issue, pagesIscience, Vol. 27, Page 109991-109991, Year 2024
Publish dateFeb 26, 2023 (structure data deposition date)
AuthorsYuan, T. / Kumar, S. / Skinner, M.E. / Victor-Joseph, R. / Abuaita, M. / Keijer, J. / Zhang, J. / Kunkel, T.J. / Liu, Y. / Petrunak, E.M. ...Yuan, T. / Kumar, S. / Skinner, M.E. / Victor-Joseph, R. / Abuaita, M. / Keijer, J. / Zhang, J. / Kunkel, T.J. / Liu, Y. / Petrunak, E.M. / Saunders, T.L. / Lieberman, A.P. / Stuckey, J.A. / Neamati, N. / Al-Murshedi, F. / Alfadhel, M. / Spelbrink, J.N. / Rodenburg, R. / de Boer, V.C.J. / Lombard, D.B.
External linksIscience / PubMed:38846003
MethodsX-ray diffraction
Resolution2.24 - 2.7 Å
Structure data

PDB-8gbl:
Structure of Apo Human SIRT5
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

PDB-8gbn:
Structure of Apo Human SIRT5 P114T Mutant
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Deacetylase

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