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TitleHomeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8.
Journal, issue, pagesCell Rep, Vol. 43, Page 114316-114316, Year 2024
Publish dateAug 25, 2023 (structure data deposition date)
AuthorsLi, X. / Kirkpatrick, R.B. / Wang, X. / Tucker, C.J. / Shukla, A. / Jessen, H.J. / Wang, H. / Shears, S.B. / Gu, C.
External linksCell Rep / PubMed:38833370
MethodsX-ray diffraction
Resolution1.4 - 1.85 Å
Structure data

PDB-8tyu:
High-resolution crystal structure of the SPX domain of XPR1 at 1.4 angstroms
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-8tyv:
Crystal structure of the SPX domain of XPR1 in complex with IP8
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-I8P:
(1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)]

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Inositol diphosphoinositol pentakisphosphate kinase / Analog methylenebisphosphonate / PPIP5K ATP-grasp / Pyrophosphate Diphosphate

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