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TitleDe novo design of buttressed loops for sculpting protein functions.
Journal, issue, pagesNat. Chem. Biol., Vol. 20, Page 974-980, Year 2024
Publish dateJan 6, 2023 (structure data deposition date)
AuthorsJiang, H. / Jude, K.M. / Wu, K. / Fallas, J. / Ueda, G. / Brunette, T.J. / Hicks, D.R. / Pyles, H. / Yang, A. / Carter, L. ...Jiang, H. / Jude, K.M. / Wu, K. / Fallas, J. / Ueda, G. / Brunette, T.J. / Hicks, D.R. / Pyles, H. / Yang, A. / Carter, L. / Lamb, M. / Li, X. / Levine, P.M. / Stewart, L. / Garcia, K.C. / Baker, D.
External linksNat. Chem. Biol. / PubMed:38816644
MethodsX-ray diffraction
Resolution1.8 - 2.99 Å
Structure data

PDB-8fre:
Designed loop protein RBL4
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8frf:
Homodimeric designed loop protein RBL7_C2_3
Method: X-RAY DIFFRACTION / Resolution: 2.99 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-MLI:
MALONATE ION

Source
  • synthetic construct (others)
KeywordsDE NOVO PROTEIN / designed protein / helical repeat / homodimer

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