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-Structure paper
| Title | Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1 delta / epsilon. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 67, Page 8609-8629, Year 2024 |
| Publish date | Nov 28, 2023 (structure data deposition date) |
 Authors | de Souza Gama, F.H. / Dutra, L.A. / Hawgood, M. / Dos Reis, C.V. / Serafim, R.A.M. / Ferreira Jr., M.A. / Teodoro, B.V.M. / Takarada, J.E. / Santiago, A.S. / Balourdas, D.I. ...de Souza Gama, F.H. / Dutra, L.A. / Hawgood, M. / Dos Reis, C.V. / Serafim, R.A.M. / Ferreira Jr., M.A. / Teodoro, B.V.M. / Takarada, J.E. / Santiago, A.S. / Balourdas, D.I. / Nilsson, A.S. / Urien, B. / Almeida, V.M. / Gileadi, C. / Ramos, P.Z. / Salmazo, A. / Vasconcelos, S.N.S. / Cunha, M.R. / Mueller, S. / Knapp, S. / Massirer, K.B. / Elkins, J.M. / Gileadi, O. / Mascarello, A. / Lemmens, B.B.L.G. / Guimaraes, C.R.W. / Azevedo, H. / Counago, R.M. |
 External links | J. Med. Chem. / PubMed:38780468 |
| Methods | X-ray diffraction |
| Resolution | 2.3 Å |
| Structure data |  PDB-8v42: |
| Chemicals |  ChemComp-PEG: 
ChemComp-YD9:  ChemComp-SO4:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE / protein kinase / inhibitor / co-crystal |
homo sapiens (human)