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| Title | Design of High Affinity Binders to Convex Protein Target Sites. |
|---|---|
| Journal, issue, pages | Biorxiv, Year 2024 |
| Publish date | Feb 22, 2023 (structure data deposition date) |
Authors | Yang, W. / Hicks, D.R. / Ghosh, A. / Schwartze, T.A. / Conventry, B. / Goreshnik, I. / Allen, A. / Halabiya, S.F. / Kim, C.J. / Hinck, C.S. ...Yang, W. / Hicks, D.R. / Ghosh, A. / Schwartze, T.A. / Conventry, B. / Goreshnik, I. / Allen, A. / Halabiya, S.F. / Kim, C.J. / Hinck, C.S. / Lee, D.S. / Bera, A.K. / Li, Z. / Wang, Y. / Schlichthaerle, T. / Cao, L. / Huang, B. / Garrett, S. / Gerben, S.R. / Rettie, S. / Heine, P. / Murray, A. / Edman, N. / Carter, L. / Stewart, L. / Almo, S. / Hinck, A.P. / Baker, D. |
External links | Biorxiv / PubMed:38746206 |
| Methods | X-ray diffraction |
| Resolution | 1.85 - 2.72 Å |
| Structure data | ![]() PDB-8gab: ![]() PDB-8gac: ![]() PDB-8gad: |
| Chemicals | ![]() ChemComp-K: ![]() ChemComp-HOH: ![]() ChemComp-EDO: ![]() ChemComp-IND: |
| Source |
|
Keywords | DE NOVO PROTEIN/Immune System / CTLA-4 / De novo protein design / high affinity binder / IMMUNE SYSTEM / DE NOVO PROTEIN-Immune System complex / PROTEIN BINDING / PD-L1 |
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