タイトル The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS. ジャーナル・号・ページ Nat Commun , Vol. 15, Page 4012-4012, Year 2024掲載日 2022年8月29日 (構造データの登録日) 著者Wu, S. / Gabelli, S.B. / Sohn, J. リンク Nat Commun / PubMed:38740774手法 X線回折 解像度 1.71 - 2.81 Å 構造データ PDB-8eae : 構造ビューア Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppG(2,5)pI 手法 : X-RAY DIFFRACTION / 解像度 : 2.56 Å
PDB-8g10 : 構造ビューア Structure of Ternary Complex of cGAS with dsDNA and Bound ITP and GTP 手法 : X-RAY DIFFRACTION / 解像度 : 2.47 Å
PDB-8g1j : 構造ビューア Structure of Ternary Complex of cGAS with dsDNA and Bound ATP and ITP 手法 : X-RAY DIFFRACTION / 解像度 : 2.3 Å
PDB-8g23 : 構造ビューア Structure of Ternary Complex of cGAS with dsDNA and Bound pppIpA 手法 : X-RAY DIFFRACTION / 解像度 : 2.71 Å
PDB-8gim : 構造ビューア Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ 手法 : X-RAY DIFFRACTION / 解像度 : 2.63 Å
PDB-8gin : 構造ビューア Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.015mM Mn2+手法 : X-RAY DIFFRACTION / 解像度 : 2.75 Å
PDB-8gio : 構造ビューア Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.1mM Mn2+手法 : X-RAY DIFFRACTION / 解像度 : 2.67 Å
PDB-8gip : 構造ビューア Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.040mM Mn2+手法 : X-RAY DIFFRACTION / 解像度 : 2.7 Å
PDB-8gir : 構造ビューア Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.2mM Mn2+手法 : X-RAY DIFFRACTION / 解像度 : 2.5 Å
PDB-8gis : 構造ビューア Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.5mM Mn2+手法 : X-RAY DIFFRACTION / 解像度 : 2.46 Å
PDB-8git : 構造ビューア Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 1mM Mn2+手法 : X-RAY DIFFRACTION / 解像度 : 2.72 Å
PDB-8shk : 構造ビューア Structure of binary complex of mouse cGAS and bound ATP 手法 : X-RAY DIFFRACTION / 解像度 : 1.71 Å
PDB-8shu : 構造ビューア Structure of mouse cGAS手法 : X-RAY DIFFRACTION / 解像度 : 1.71 Å
PDB-8shy : 構造ビューア Structure of binary complex of mouse cGAS QN and bound ATP手法 : X-RAY DIFFRACTION / 解像度 : 1.77 Å
PDB-8shz : 構造ビューア Structure of human cGAS手法 : X-RAY DIFFRACTION / 解像度 : 2.4 Å
PDB-8si0 : 構造ビューア Structure of binary complex of human cGAS and bound cGAMP 手法 : X-RAY DIFFRACTION / 解像度 : 2.7 Å
PDB-8sj0 : 構造ビューア Structure of ternary complex of cGAS with dsDNA and bound 2'-dATP 手法 : X-RAY DIFFRACTION / 解像度 : 2.55 Å
PDB-8sj1 : 構造ビューア Structure of ternary complex of cGAS with dsDNA and bound 3'-dATP 手法 : X-RAY DIFFRACTION / 解像度 : 2.81 Å
PDB-8sj2 : 構造ビューア Structure of ternary complex of cGAS with dsDNA and bound ATP and 2'-dGTP 手法 : X-RAY DIFFRACTION / 解像度 : 2.23 Å
PDB-8sj8 : 構造ビューア Structure of binary complex of human cGAS and bound ppp(2'-5')GpG 手法 : X-RAY DIFFRACTION / 解像度 : 2.5 Å
PDB-8skt : 構造ビューア Structure of ternary complex of mouse cGAS with dsDNA and bound ATP with 5 mM Mn2+手法 : X-RAY DIFFRACTION / 解像度 : 2.69 Å
化合物 ChemComp-VLO : 構造ビューア [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
ChemComp-VWX : 構造ビューア [[(2~{R},3~{R},4~{R},5~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
ChemComp-OKR : 構造ビューア [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
由来 mus musculus (ハツカネズミ)dna molecule (その他) synthetic construct (人工物) homo sapiens (ヒト) キーワード TRANSFERASE/DNA / Transferase-DNA complex / cGAS / pppG(2 / 5)pI / IMMUNE SYSTEM / IMMUNE SYSTEM/DNA / ATP and ITP / TRANSFERASE / intermediate / IMMUNE SYSTEM-DNA complex / ATP and divalent metal / ATP and divalent metal ion / ligands