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Structure paper

TitleAkkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood.
Journal, issue, pagesNat Microbiol, Vol. 9, Page 1176-1188, Year 2024
Publish dateJul 18, 2023 (structure data deposition date)
AuthorsJensen, M. / Stenfelt, L. / Ricci Hagman, J. / Pichler, M.J. / Weikum, J. / Nielsen, T.S. / Hult, A. / Morth, J.P. / Olsson, M.L. / Abou Hachem, M.
External linksNat Microbiol / PubMed:38684911
MethodsX-ray diffraction
Resolution1.68 - 2.5 Å
Structure data

PDB-8pvs:
Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-8pxt:
Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-8pxu:
Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-8pxv:
Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-GLA:
alpha-D-galactopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-FMT:
FORMIC ACID

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NGA:
2-acetamido-2-deoxy-beta-D-galactopyranose

ChemComp-CL:
Unknown entry

ChemComp-CAC:
CACODYLATE ION

ChemComp-GOL:
GLYCEROL

Source
  • akkermansia muciniphila (bacteria)
KeywordsHYDROLASE / Alpha-galactosidase / Akkermansia muciniphila / Blood conversion / Beta-helix / Beta-hexosaminidase / GalNAc-B converting / CBM

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