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-Structure paper
Title | Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. |
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Journal, issue, pages | Acs Chem. Biol., Vol. 19, Page 1066-1081, Year 2024 |
Publish date | Dec 8, 2023 (structure data deposition date) |
![]() | Devitt, A.N. / Vargas, A.L. / Zhu, W. / Des Soye, B.J. / Butun, F.A. / Alt, T. / Kaley, N. / Ferreira, G.M. / Moran, G.R. / Kelleher, N.L. ...Devitt, A.N. / Vargas, A.L. / Zhu, W. / Des Soye, B.J. / Butun, F.A. / Alt, T. / Kaley, N. / Ferreira, G.M. / Moran, G.R. / Kelleher, N.L. / Liu, D. / Silverman, R.B. |
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Methods | X-ray diffraction |
Resolution | 1.61 Å |
Structure data | ![]() PDB-8v9m: |
Chemicals | ![]()
ChemComp-YR5: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / PLP / Ornithine Aminotransferase / Mechanism-based Inactivator / heptocellular carcinoma |