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Structure paper

TitleA novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.
Journal, issue, pagesCell Death Differ., Vol. 31, Page 711-721, Year 2024
Publish dateOct 15, 2023 (structure data deposition date)
AuthorsSubas Satish, H.P. / Iyer, S. / Shi, M.X. / Wong, A.W. / Fischer, K.C. / Wardak, A.Z. / Lio, D. / Brouwer, J.M. / Uren, R.T. / Czabotar, P.E. ...Subas Satish, H.P. / Iyer, S. / Shi, M.X. / Wong, A.W. / Fischer, K.C. / Wardak, A.Z. / Lio, D. / Brouwer, J.M. / Uren, R.T. / Czabotar, P.E. / Miller, M.S. / Kluck, R.M.
External linksCell Death Differ. / PubMed:38582955
MethodsX-ray diffraction
Resolution2.398 Å
Structure data

PDB-8uky:
Crystal structure of BAK in complex with inhibiting antibody 14G6
Method: X-RAY DIFFRACTION / Resolution: 2.398 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-CCN:
ACETONITRILE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-144:
TRIS-HYDROXYMETHYL-METHYL-AMMONIUM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS/INHIBITOR / BAK / APOPTOSIS-INHIBITOR complex / BCL2 / antibody

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