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TitleLocally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies.
Journal, issue, pagesStructure, Vol. 32, Page 536-549.e5, Year 2024
Publish dateJul 3, 2023 (structure data deposition date)
AuthorsArimori, T. / Mihara, E. / Suzuki, H. / Ohishi, T. / Tanaka, T. / Kaneko, M.K. / Takagi, J. / Kato, Y.
External linksStructure / PubMed:38460519
MethodsX-ray diffraction
Resolution1.69 - 1.75 Å
Structure data

PDB-8jyq:
Crystal structure of cancer-specific anti-HER2 antibody H2Mab-214 in complex with epitope peptide
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-8jyr:
Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HER2 / antibody

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