EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity.
ジャーナル・号・ページ	Nat Commun, Vol. 15, Page 1502-1502, Year 2024
掲載日	2023年7月7日 (構造データの登録日)
著者	Marquez-Monino, M.A. / Ortega-Garcia, R. / Whitfield, H. / Riley, A.M. / Infantes, L. / Garrett, S.W. / Shipton, M.L. / Brearley, C.A. / Potter, B.V.L. / Gonzalez, B.
リンク	Nat Commun / PubMed:38374076
手法	X線回折
解像度	1.59 - 1.92 Å
構造データ	PDB-8pp8: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with L-scyllo-inositol 1,2,4-trisphosphate/AMP-PNP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-8pp9: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with scyllo-inositol 1,2,3,5-tetrakisphosphate/ADP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-8ppa: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with D-myo-inositol 1,4,6-trisphosphate/AMP-PNP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-8ppb: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with D-3-deoxy-myo-inositol 1,4,6-trisphosphate/ATP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-8ppc: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with L-chiro-inositol 2,3,5-trisphosphate/ATP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-8ppd: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with DL-6-deoxy-6-hydroxy-methyl-scyllo-inositol 1,2,4-trisphosphate/ATP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.77 Å PDB-8ppe: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with DL-6-deoxy-6-phosphoryloxymethyl-scyllo-inositol 1,2,4-trisphosphate/ADP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-8ppf: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with beta-D-glucopyranosyl 1,3,4-trisphosphate/AMP-PNP/Mg 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-8ppg: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with beta-D-glucopyranosyl 1,3,4,6-tetrakisphosphate/ADP/Mn after reaction 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-8pph: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with alpha-D-glucopyranosyl 1,3,4-trisphosphate/ATP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-8ppi: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with beta-D-glucopyranosylmethanol 3,4,1'-trisphosphate/ATP/Mn 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-8ppj: Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with beta-D-glucopyranosylmethanol 3,4,6,1'-tetrakisphosphate/ADP/Mn after reaction 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å
化合物	ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体YM 化合物画像なし ChemComp-3IA: Unknown entry ChemComp-MN: Unknown entry ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-HOH: WATER 化合物画像なし ChemComp-4IM: Unknown entry ChemComp-ADP: ADENOSINE-5'-DIPHOSPHATE / ADP / ADP, エネルギー貯蔵分子YM 化合物画像なし ChemComp-06G: Unknown entry 化合物画像なし ChemComp-3I2: Unknown entry ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP / ATP, エネルギー貯蔵分子YM 化合物画像なし ChemComp-2KM: Unknown entry 化合物画像なし ChemComp-75I: Unknown entry 化合物画像なし ChemComp-7I8: Unknown entry ChemComp-GOL: GLYCEROL / グリセロ-ル化合物画像なし ChemComp-6II: Unknown entry 化合物画像なし ChemComp-46I: Unknown entry 化合物画像なし ChemComp-5AI: Unknown entry 化合物画像なし ChemComp-69I: Unknown entry 化合物画像なし ChemComp-661*: Unknown entry
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE / Inositol polyphosphate / InsP / inositol kinase / IP3K / calcium / InsP3 / IP3 / IPK / IP3 3-K