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| Title | Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer. |
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| Journal, issue, pages | Eur. J. Med. Chem., Vol. 268, Page 116193-116193, Year 2024 |
| Publish date | Dec 3, 2023 (structure data deposition date) |
 Authors | Pippione, A.C. / Kovachka, S. / Vigato, C. / Bertarini, L. / Mannella, I. / Sainas, S. / Rolando, B. / Denasio, E. / Piercy-Mycock, H. / Romalho, L. ...Pippione, A.C. / Kovachka, S. / Vigato, C. / Bertarini, L. / Mannella, I. / Sainas, S. / Rolando, B. / Denasio, E. / Piercy-Mycock, H. / Romalho, L. / Salladini, E. / Adinolfi, S. / Zonari, D. / Peraldo-Neia, C. / Chiorino, G. / Passoni, A. / Mirza, O.A. / Frydenvang, K. / Pors, K. / Lolli, M.L. / Spyrakis, F. / Oliaro-Bosso, S. / Boschi, D. |
 External links | Eur. J. Med. Chem. / PubMed:38364714 |
| Methods | X-ray diffraction |
| Resolution | 2 Å |
| Structure data |  PDB-8rb6: |
| Chemicals |  ChemComp-NAP: 
ChemComp-YMC:  ChemComp-EDO:  ChemComp-HOH: |
| Source |
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 Keywords | OXIDOREDUCTASE / Aldo-keto reductase / AKR1C3 / inhibitor |
homo sapiens (human)