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TitleBAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 2907-2940, Year 2024
Publish dateDec 18, 2023 (structure data deposition date)
AuthorsMeibom, D. / Wasnaire, P. / Beyer, K. / Broehl, A. / Cancho-Grande, Y. / Elowe, N. / Henninger, K. / Johannes, S. / Jungmann, N. / Krainz, T. ...Meibom, D. / Wasnaire, P. / Beyer, K. / Broehl, A. / Cancho-Grande, Y. / Elowe, N. / Henninger, K. / Johannes, S. / Jungmann, N. / Krainz, T. / Lindner, N. / Maassen, S. / MacDonald, B. / Menshykau, D. / Mittendorf, J. / Sanchez, G. / Schaefer, M. / Stefan, E. / Torge, A. / Xing, Y. / Zubov, D.
External linksJ. Med. Chem. / PubMed:38348661
MethodsX-ray diffraction
Resolution1.96 Å
Structure data

PDB-8rij:
Discovery of the first orally bioavailable ADAMTS7 inhibitor BAY-9835
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

PDB-1h07:
CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / MATRIX METALLOPROTEINASE / MMP12 / METALLO ELASTASE / EXTRACELLULAR MATRIX / METAL-BINDING / METALLOPROTEASE

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