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TitleDiscovery and Preclinical Activity of BMS-986351, an Antibody to SIRP alpha That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies.
Journal, issue, pagesCancer Res Commun, Vol. 4, Page 505-515, Year 2024
Publish dateNov 12, 2021 (structure data deposition date)
AuthorsChan, H. / Trout, C.V. / Mikolon, D. / Adams, P. / Guzman, R. / Mavrommatis, K. / Abbasian, M. / Hadjivassiliou, H. / Dearth, L. / Fox, B.A. ...Chan, H. / Trout, C.V. / Mikolon, D. / Adams, P. / Guzman, R. / Mavrommatis, K. / Abbasian, M. / Hadjivassiliou, H. / Dearth, L. / Fox, B.A. / Sivakumar, P. / Cho, H. / Hariharan, K.
External linksCancer Res Commun / PubMed:38319147
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-7st5:
Structure of Fab CC-95251 in complex with SIRP-alpha
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / cell surface receptor

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