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-Structure paper
Title | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. |
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Journal, issue, pages | Nat Commun, Vol. 15, Page 937-937, Year 2024 |
Publish date | Oct 12, 2022 (structure data deposition date) |
![]() | Xie, S.C. / Wang, Y. / Morton, C.J. / Metcalfe, R.D. / Dogovski, C. / Pasaje, C.F.A. / Dunn, E. / Luth, M.R. / Kumpornsin, K. / Istvan, E.S. ...Xie, S.C. / Wang, Y. / Morton, C.J. / Metcalfe, R.D. / Dogovski, C. / Pasaje, C.F.A. / Dunn, E. / Luth, M.R. / Kumpornsin, K. / Istvan, E.S. / Park, J.S. / Fairhurst, K.J. / Ketprasit, N. / Yeo, T. / Yildirim, O. / Bhebhe, M.N. / Klug, D.M. / Rutledge, P.J. / Godoy, L.C. / Dey, S. / De Souza, M.L. / Siqueira-Neto, J.L. / Du, Y. / Puhalovich, T. / Amini, M. / Shami, G. / Loesbanluechai, D. / Nie, S. / Williamson, N. / Jana, G.P. / Maity, B.C. / Thomson, P. / Foley, T. / Tan, D.S. / Niles, J.C. / Han, B.W. / Goldberg, D.E. / Burrows, J. / Fidock, D.A. / Lee, M.C.S. / Winzeler, E.A. / Griffin, M.D.W. / Todd, M.H. / Tilley, L. |
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Methods | X-ray diffraction |
Resolution | 1.9 - 2.16 Å |
Structure data | ![]() PDB-8h53: ![]() PDB-8tc7: ![]() PDB-8tc8: ![]() PDB-8tc9: |
Chemicals | ![]() ChemComp-4AD: ![]() ChemComp-2PN: ![]() ChemComp-GOL: ![]() ChemComp-MG: ![]() ChemComp-HOH: ![]() ChemComp-CL: ![]() ChemComp-NSS: ![]() ChemComp-NA: ![]()
ChemComp-ZTE: |
Source |
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![]() | RNA BINDING PROTEIN / asparagine / complex / synthetase / tRNA / LIGASE / enzyme / synthase / drug target |