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TitleReaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Journal, issue, pagesNat Commun, Vol. 15, Page 937-937, Year 2024
Publish dateOct 12, 2022 (structure data deposition date)
AuthorsXie, S.C. / Wang, Y. / Morton, C.J. / Metcalfe, R.D. / Dogovski, C. / Pasaje, C.F.A. / Dunn, E. / Luth, M.R. / Kumpornsin, K. / Istvan, E.S. ...Xie, S.C. / Wang, Y. / Morton, C.J. / Metcalfe, R.D. / Dogovski, C. / Pasaje, C.F.A. / Dunn, E. / Luth, M.R. / Kumpornsin, K. / Istvan, E.S. / Park, J.S. / Fairhurst, K.J. / Ketprasit, N. / Yeo, T. / Yildirim, O. / Bhebhe, M.N. / Klug, D.M. / Rutledge, P.J. / Godoy, L.C. / Dey, S. / De Souza, M.L. / Siqueira-Neto, J.L. / Du, Y. / Puhalovich, T. / Amini, M. / Shami, G. / Loesbanluechai, D. / Nie, S. / Williamson, N. / Jana, G.P. / Maity, B.C. / Thomson, P. / Foley, T. / Tan, D.S. / Niles, J.C. / Han, B.W. / Goldberg, D.E. / Burrows, J. / Fidock, D.A. / Lee, M.C.S. / Winzeler, E.A. / Griffin, M.D.W. / Todd, M.H. / Tilley, L.
External linksNat Commun / PubMed:38297033
MethodsX-ray diffraction
Resolution1.9 - 2.16 Å
Structure data

PDB-8h53:
Human asparaginyl-tRNA synthetase in complex with asparagine-AMP
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

PDB-8tc7:
Human asparaginyl-tRNA synthetase, apo form
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8tc8:
Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8tc9:
Human asparaginyl-tRNA synthetase bound to OSM-S-106
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-4AD:
4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE

ChemComp-2PN:
IMIDODIPHOSPHORIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-NSS:
5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE

ChemComp-NA:
Unknown entry


ChemComp, No image

ChemComp-ZTE:
Unknown entry

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / asparagine / complex / synthetase / tRNA / LIGASE / enzyme / synthase / drug target

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