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Structure paper

TitleXTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer.
Journal, issue, pagesJ Immunother Cancer, Vol. 11, Year 2023
Publish dateFeb 5, 2023 (structure data deposition date)
AuthorsJenkins, K.A. / Park, M. / Pederzoli-Ribeil, M. / Eskiocak, U. / Johnson, P. / Guzman, W. / McLaughlin, M. / Moore-Lai, D. / O'Toole, C. / Liu, Z. ...Jenkins, K.A. / Park, M. / Pederzoli-Ribeil, M. / Eskiocak, U. / Johnson, P. / Guzman, W. / McLaughlin, M. / Moore-Lai, D. / O'Toole, C. / Liu, Z. / Nicholson, B. / Flesch, V. / Qiu, H. / Clackson, T. / O'Hagan, R.C. / Rodeck, U. / Karow, M. / O'Neil, J. / Williams, J.C.
External linksJ Immunother Cancer / PubMed:38164757
MethodsX-ray diffraction
Resolution1.8 - 3 Å
Structure data

PDB-8g2m:
The tumor activated anti-CTLA-4 monoclonal antibody XTX101 demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8g8n:
CTLA4 Fab with peptide
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-CIT:
CITRIC ACID

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • peptide display vector fth1 (others)
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Engineered antibody / Anti-CTLA4 mAb

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