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TitleCharacterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.
Journal, issue, pagesNat Commun, Vol. 14, Page 8502-8502, Year 2023
Publish dateAug 31, 2023 (structure data deposition date)
AuthorsOkura, Y. / Ikawa-Teranishi, Y. / Mizoroki, A. / Takahashi, N. / Tsushima, T. / Irie, M. / Harfuddin, Z. / Miura-Okuda, M. / Ito, S. / Nakamura, G. ...Okura, Y. / Ikawa-Teranishi, Y. / Mizoroki, A. / Takahashi, N. / Tsushima, T. / Irie, M. / Harfuddin, Z. / Miura-Okuda, M. / Ito, S. / Nakamura, G. / Takesue, H. / Ozono, Y. / Nishihara, M. / Yamada, K. / Gan, S.W. / Hayasaka, A. / Ishii, S. / Wakabayashi, T. / Muraoka, M. / Nagaya, N. / Hino, H. / Nemoto, T. / Kuramochi, T. / Torizawa, T. / Shimada, H. / Kitazawa, T. / Okazaki, M. / Nezu, J. / Sollid, L.M. / Igawa, T.
External linksNat Commun / PubMed:38135691
MethodsX-ray diffraction
Resolution2.105 - 2.818 Å
Structure data

PDB-8w83:
HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02
Method: X-RAY DIFFRACTION / Resolution: 2.818 Å

PDB-8w84:
HLA-DQ2.5-alpha2 gliadin peptide in complex with DQN0344AE02
Method: X-RAY DIFFRACTION / Resolution: 2.105 Å

PDB-8w85:
HLA-DQ2.5-gamma2 gliadin peptide in complex with DQN0385AE01
Method: X-RAY DIFFRACTION / Resolution: 2.769 Å

PDB-8w86:
HLA-DQ2.5-B/C hordein peptide in complex with DQN0385AE02
Method: X-RAY DIFFRACTION / Resolution: 2.236 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CELIAC DISEASE / ANTIBODY

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