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-Structure paper
タイトル | Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM. |
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ジャーナル・号・ページ | Nat Commun, Vol. 14, Issue 1, Page 7503, Year 2023 |
掲載日 | 2023年11月18日 |
著者 | Yijia Cheng / Jianting Han / Meinai Song / Shuqin Zhang / Qin Cao / |
PubMed 要旨 | Bacteria develop a variety of extracellular fibrous structures crucial for their survival, such as flagella and pili. In this study, we use cryo-EM to identify protein fibrils surrounding lab- ...Bacteria develop a variety of extracellular fibrous structures crucial for their survival, such as flagella and pili. In this study, we use cryo-EM to identify protein fibrils surrounding lab-cultured Bacillus amyloiquefaciens and discover an unreported fibril species in addition to the flagellar fibrils. These previously unknown fibrils are composed of Vpr, an extracellular serine peptidase. We find that Vpr assembles into fibrils in an enzymatically active form, potentially representing a strategy of enriching Vpr activities around bacterial cells. Vpr fibrils are also observed under other culture conditions and around other Bacillus bacteria, such as Bacillus subtilis, which may suggest a general mechanism across all Bacillus bacterial groups. Taken together, our study reveals fibrils outside the bacterial cell and sheds light on the physiological role of these extracellular fibrils. |
リンク | Nat Commun / PubMed:37980359 / PubMed Central |
手法 | EM (らせん対称) |
解像度 | 2.9 Å |
構造データ | EMDB-36427, PDB-8jmv: EMDB-36428, PDB-8jmw: |
由来 |
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キーワード | PROTEIN FIBRIL / Flagella / motor / fibril / Serine peptidase |