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Structure paper

TitleMechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.
Journal, issue, pagesNat. Chem. Biol., Vol. 20, Page 234-242, Year 2024
Publish dateApr 28, 2022 (structure data deposition date)
AuthorsBordeleau, E. / Stogios, P.J. / Evdokimova, E. / Koteva, K. / Savchenko, A. / Wright, G.D.
External linksNat. Chem. Biol. / PubMed:37973888
MethodsX-ray diffraction
Resolution1.78 - 2.83 Å
Structure data

PDB-7uuj:
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-7uuk:
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with tobramycin
Method: X-RAY DIFFRACTION / Resolution: 2.82 Å

PDB-7uul:
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with kanamycin B and coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-7uum:
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with paromomycin and coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 2.74 Å

PDB-7uun:
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with neomycin
Method: X-RAY DIFFRACTION / Resolution: 2.83 Å

PDB-7uuo:
Crystal structure of aminoglycoside resistance enzyme ApmA H135A mutant, complex with tobramycin and coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-LLL:
(2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-TOY:
TOBRAMYCIN / antibiotic*YM

ChemComp-9CS:
(1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE / antibiotic*YM

ChemComp-COA:
COENZYME A

ChemComp-SO4:
SULFATE ION

ChemComp-PAR:
PAROMOMYCIN / Antimicrobial, medication*YM

ChemComp-GOL:
GLYCEROL

ChemComp-NMY:
NEOMYCIN / antibiotic*YM

Source
  • staphylococcus aureus (bacteria)
KeywordsTRANSFERASE / XAT / XENOBIOTIC ACETYLTRANSFERASE / LEFT-HANDED BETA HELIX / LBH / ANTIBIOTIC RESISTANCE / AMINOGLYCOSIDE / STRUCTURAL GENOMICS / CSGID / CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES / NIAID / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES / Center for Structural Biology of Infectious Diseases / CSBID

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