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Structure paper

TitleInadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Journal, issue, pagesNat Commun, Vol. 14, Page 7218-7218, Year 2023
Publish dateJan 21, 2023 (structure data deposition date)
AuthorsTan, K. / Chen, J. / Kaku, Y. / Wang, Y. / Donius, L. / Khan, R.A. / Li, X. / Richter, H. / Seaman, M.S. / Walz, T. ...Tan, K. / Chen, J. / Kaku, Y. / Wang, Y. / Donius, L. / Khan, R.A. / Li, X. / Richter, H. / Seaman, M.S. / Walz, T. / Hwang, W. / Reinherz, E.L. / Kim, M.
External linksNat Commun / PubMed:37940661
MethodsX-ray diffraction
Resolution1.94 - 3.5 Å
Structure data

PDB-8fwf:
Crystal structure of Apo form Fab235
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-8fxj:
Crystal structure of Fab460
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8fym:
Crystal structure of Fab235 in complex with MPER peptide
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-8fz2:
Crystal structure of Fab460 in complex with MPER peptide
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-1HC:
prop-2-enamide

Source
  • mus musculus (house mouse)
  • human immunodeficiency virus 1
  • human immunodeficiency virus type 1 group m subtype b (strain 89.6)
KeywordsIMMUNE SYSTEM / HIV / membrane proximal external region / MPER / vaccine / Fab460 / Membrane-Proximal External Region / Vaccucine / Fab

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