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Structure paper

TitleSMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing.
Journal, issue, pagesImmunity, Vol. 56, Page 2492-2507.e10, Year 2023
Publish dateAug 29, 2023 (structure data deposition date)
AuthorsHou, Y. / Wang, Z. / Liu, P. / Wei, X. / Zhang, Z. / Fan, S. / Zhang, L. / Han, F. / Song, Y. / Chu, L. / Zhang, C.
External linksImmunity / PubMed:37890481
MethodsX-ray diffraction
Resolution1.91 - 1.95 Å
Structure data

PDB-8w6p:
Crystal structure of dimeric murine SMPDL3A
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

PDB-8w6r:
murine SMPDL3A bound to sulfate
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-YA4:
[(2~{R},3~{S},4~{S})-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphinic acid

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZN:
Unknown entry

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / innate immunity / lipid metabolism

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