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TitleActivation of human STING by a molecular glue-like compound.
Journal, issue, pagesNat Chem Biol, Vol. 20, Issue 3, Page 365-372, Year 2024
Publish dateOct 12, 2023
AuthorsJie Li / Stephen M Canham / Hua Wu / Martin Henault / Lihao Chen / Guoxun Liu / Yu Chen / Gary Yu / Howard R Miller / Viktor Hornak / Scott M Brittain / Gregory A Michaud / Antonin Tutter / Wendy Broom / Mary Ellen Digan / Sarah M McWhirter / Kelsey E Sivick / Helen T Pham / Christine H Chen / George S Tria / Jeffery M McKenna / Markus Schirle / Xiaohong Mao / Thomas B Nicholson / Yuan Wang / Jeremy L Jenkins / Rishi K Jain / John A Tallarico / Sejal J Patel / Lianxing Zheng / Nathan T Ross / Charles Y Cho / Xuewu Zhang / Xiao-Chen Bai / Yan Feng /
PubMed AbstractStimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to infection and has been therapeutically exploited for its ...Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to infection and has been therapeutically exploited for its antitumor activity. The activation of STING requires its high-order oligomerization, which could be induced by binding of the endogenous ligand, cGAMP, to the cytosolic ligand-binding domain. Here we report the discovery through functional screens of a class of compounds, named NVS-STGs, that activate human STING. Our cryo-EM structures show that NVS-STG2 induces the high-order oligomerization of human STING by binding to a pocket between the transmembrane domains of the neighboring STING dimers, effectively acting as a molecular glue. Our functional assays showed that NVS-STG2 could elicit potent STING-mediated immune responses in cells and antitumor activities in animal models.
External linksNat Chem Biol / PubMed:37828400 / PubMed Central
MethodsEM (single particle)
Resolution2.9 - 4.0 Å
Structure data

29281

8flk

EMDB-29281, PDB-8flk:
Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
Method: EM (single particle) / Resolution: 4.0 Å

29282

8flm

EMDB-29282, PDB-8flm:
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Method: EM (single particle) / Resolution: 2.9 Å

Chemicals

ChemComp-1SY:
cGAMP

ChemComp-Y6H:
4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid

ChemComp-9IM:
1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / STING / innate immunity / molecular glue

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