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Structure paper

Title"Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Journal, issue, pagesCommun Biol, Vol. 6, Page 997-997, Year 2023
Publish dateFeb 28, 2022 (structure data deposition date)
AuthorsFischman, S. / Levin, I. / Rondeau, J.M. / Strajbl, M. / Lehmann, S. / Huber, T. / Nimrod, G. / Cebe, R. / Omer, D. / Kovarik, J. ...Fischman, S. / Levin, I. / Rondeau, J.M. / Strajbl, M. / Lehmann, S. / Huber, T. / Nimrod, G. / Cebe, R. / Omer, D. / Kovarik, J. / Bernstein, S. / Sasson, Y. / Demishtein, A. / Shlamkovich, T. / Bluvshtein, O. / Grossman, N. / Barak-Fuchs, R. / Zhenin, M. / Fastman, Y. / Twito, S. / Vana, T. / Zur, N. / Ofran, Y.
External linksCommun Biol / PubMed:37773269
MethodsX-ray diffraction
Resolution1.899 - 3.3 Å
Structure data

PDB-7z2m:
Crystal Structure of the 11.003 Fab in complex with human IL-17A
Method: X-RAY DIFFRACTION / Resolution: 1.899 Å

PDB-7z3w:
Crystal structure of the AAL160 Fab
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7z4t:
AAL160 FAB IN COMPLEX WITH HUMAN INTERLEUKIN-1 BETA
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ETE:
2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunoglobulin / Cytokine / IL-17A / monoclonal antibody / OTHER / IL-1B

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