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TitleMultifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses.
Journal, issue, pagesNat Commun, Vol. 14, Page 5650-5650, Year 2023
Publish dateAug 30, 2022 (structure data deposition date)
AuthorsChapman, N.S. / Hulswit, R.J.G. / Westover, J.L.B. / Stass, R. / Paesen, G.C. / Binshtein, E. / Reidy, J.X. / Engdahl, T.B. / Handal, L.S. / Flores, A. ...Chapman, N.S. / Hulswit, R.J.G. / Westover, J.L.B. / Stass, R. / Paesen, G.C. / Binshtein, E. / Reidy, J.X. / Engdahl, T.B. / Handal, L.S. / Flores, A. / Gowen, B.B. / Bowden, T.A. / Crowe Jr., J.E.
External linksNat Commun / PubMed:37704627
MethodsX-ray diffraction
Resolution1.62 - 3.5 Å
Structure data

PDB-8awl:
Fab RVFV-268
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

PDB-8awm:
RVFV GnH with Fab268 bound
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-CIT:
CITRIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • rift valley fever virus
KeywordsIMMUNE SYSTEM / Fab fragment antibody / VIRAL PROTEIN / RVFV / Gn / Fab268

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