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TitleStructural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function.
Journal, issue, pagesCancer Discov, Vol. 13, Page 2548-2565, Year 2023
Publish dateApr 14, 2023 (structure data deposition date)
AuthorsBercier, P. / Wang, Q.Q. / Zang, N. / Zhang, J. / Yang, C. / Maimaitiyiming, Y. / Abou-Ghali, M. / Berthier, C. / Wu, C. / Niwa-Kawakita, M. ...Bercier, P. / Wang, Q.Q. / Zang, N. / Zhang, J. / Yang, C. / Maimaitiyiming, Y. / Abou-Ghali, M. / Berthier, C. / Wu, C. / Niwa-Kawakita, M. / Dirami, T. / Geoffroy, M.C. / Ferhi, O. / Quentin, S. / Benhenda, S. / Ogra, Y. / Gueroui, Z. / Zhou, C. / Naranmandura, H. / de The, H. / Lallemand-Breitenbach, V.
External linksCancer Discov / PubMed:37655965
MethodsX-ray diffraction
Resolution2.09 - 2.6 Å
Structure data

PDB-8j25:
Crystal structure of PML B-box2 mutant
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-8j2p:
Crystal structure of PML B-box2
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (strain k12) (bacteria)
  • homo sapiens (human)
KeywordsLIGASE / PML / TRIM19 / B-Box2

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