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Structure paper

TitleStructural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.
Journal, issue, pagesNat Commun, Vol. 14, Page 5209-5209, Year 2023
Publish dateDec 1, 2022 (structure data deposition date)
AuthorsWu, A. / Salom, D. / Hong, J.D. / Tworak, A. / Watanabe, K. / Pardon, E. / Steyaert, J. / Kandori, H. / Katayama, K. / Kiser, P.D. / Palczewski, K.
External linksNat Commun / PubMed:37626045
MethodsX-ray diffraction
Resolution3.7 - 4.25 Å
Structure data

PDB-8fcz:
Crystal structure of ground-state rhodopsin in complex with a nanobody
Method: X-RAY DIFFRACTION / Resolution: 3.7 Å

PDB-8fd0:
Crystal structure of bovine rod opsin in complex with a nanobody
Method: X-RAY DIFFRACTION / Resolution: 3.71 Å

PDB-8fd1:
Crystal structure of photoactivated rhodopsin in complex with a nanobody
Method: X-RAY DIFFRACTION / Resolution: 4.25 Å

Chemicals

ChemComp-RET:
RETINAL

Source
  • lama glama (llama)
  • bos taurus (cattle)
KeywordsMEMBRANE PROTEIN / TRANSMEMBRANE PROTEIN / GPCR / NANOBODY / RETINAL

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