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TitleHuman 2'-Deoxynucleoside 5'-Phosphate N -Hydrolase 1: Mechanism of 2'-Deoxyuridine 5'-Monophosphate Hydrolysis.
Journal, issue, pagesBiochemistry, Vol. 62, Page 2658-2668, Year 2023
Publish dateApr 18, 2023 (structure data deposition date)
AuthorsDevi, S. / Carberry, A.E. / Zickuhr, G.M. / Dickson, A.L. / Harrison, D.J. / da Silva, R.G.
External linksBiochemistry / PubMed:37582341
MethodsX-ray diffraction
Resolution1.42 - 1.7 Å
Structure data

PDB-8os9:
Structure of Homo sapiens 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (DNPH1)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8osc:
Structure of Homo sapiens 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (DNPH1) bound to deoxyuridine 5'- monophosphate
Method: X-RAY DIFFRACTION / Resolution: 1.42 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-UMP:
2'-DEOXYURIDINE 5'-MONOPHOSPHATE

Source
  • homo sapiens (human)
KeywordsHYDROLASE / deoxyribonucleoside 5'-monophosphate N-glycosidase activity

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