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Title | Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 10579-10603, Year 2023 |
Publish date | Apr 12, 2023 (structure data deposition date) |
Authors | Zhang, H. / Zhou, S. / Plewka, J. / Wu, C. / Zhu, M. / Yu, Q. / Musielak, B. / Wang, X. / Awadasseid, A. / Magiera-Mularz, K. ...Zhang, H. / Zhou, S. / Plewka, J. / Wu, C. / Zhu, M. / Yu, Q. / Musielak, B. / Wang, X. / Awadasseid, A. / Magiera-Mularz, K. / Wu, Y. / Zhang, W. |
External links | J. Med. Chem. / PubMed:37496104 |
Methods | X-ray diffraction |
Resolution | 3.5 Å |
Structure data | PDB-8or1: |
Chemicals | ChemComp-VYC: |
Source |
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Keywords | IMMUNE SYSTEM / PD-L1 / inhibitor / immunotheraphy |