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| Title | Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors. |
|---|---|
| Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 120, Page e2302485120-e2302485120, Year 2023 |
| Publish date | Oct 31, 2022 (structure data deposition date) |
Authors | Akkapeddi, P. / Hattori, T. / Khan, I. / Glasser, E. / Koide, A. / Ketavarapu, G. / Whaby, M. / Zuberi, M. / Teng, K.W. / Lefler, J. ...Akkapeddi, P. / Hattori, T. / Khan, I. / Glasser, E. / Koide, A. / Ketavarapu, G. / Whaby, M. / Zuberi, M. / Teng, K.W. / Lefler, J. / Maso, L. / Bang, I. / Ostrowski, M.C. / O'Bryan, J.P. / Koide, S. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:37399416 |
| Methods | X-ray diffraction |
| Resolution | 2.44 - 2.52 Å |
| Structure data | ![]() PDB-8ezg: ![]() PDB-8f0m: |
| Chemicals | ![]() ChemComp-GDP: ![]() ChemComp-MG: ![]() ChemComp-NA: ![]() ChemComp-HOH: ![]() ChemComp-GLC: ![]() ChemComp-GSP: |
| Source |
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Keywords | SIGNALING PROTEIN/DE NOVO PROTEIN / SIGNALING PROTEIN-DE NOVO PROTEIN complex |
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