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Structure paper

TitleSARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor.
Journal, issue, pagesActa Pharm Sin B, Vol. 13, Page 3043-3053, Year 2023
Publish dateDec 14, 2022 (structure data deposition date)
AuthorsLi, Y. / Yang, M. / Nan, Y. / Wang, J. / Wang, S. / Cui, D. / Guo, J. / He, P. / Dai, W. / Zhou, S. ...Li, Y. / Yang, M. / Nan, Y. / Wang, J. / Wang, S. / Cui, D. / Guo, J. / He, P. / Dai, W. / Zhou, S. / Zhang, Y. / Ma, W.
External linksActa Pharm Sin B / PubMed:37360012
MethodsX-ray diffraction
Resolution1.398 - 3.34 Å
Structure data

PDB-8hqt:
The complex structure of COPI cargo sorting module with SARS-CoV-2 Spike KxHxx sorting motif
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8hqv:
The complex structure of COPI cargo sorting module with HCoV-OC43 Spike KTSHxx sorting motif
Method: X-RAY DIFFRACTION / Resolution: 1.398 Å

PDB-8hqw:
The complex structure of COPI cargo sorting module with MHV Spike Hxx sorting motif
Method: X-RAY DIFFRACTION / Resolution: 1.405 Å

PDB-8hqx:
The complex structure of COPI cargo sorting module with TAT-WDM peptide
Method: X-RAY DIFFRACTION / Resolution: 1.538 Å

PDB-8hr0:
The complex structure of COPII coat with HCoV-OC43 DD sorting motif
Method: X-RAY DIFFRACTION / Resolution: 3.34 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

Source
  • saccharomyces cerevisiae (strain yjm789) (yeast)
  • severe acute respiratory syndrome coronavirus 2
  • human coronavirus oc43
  • murine hepatitis virus
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / SARS-CoV-2 / Spike / COPI vesicle / KxHxx motif / retention signal / HCoV-OC43 / KTSHxx motif / MHV / Hxx motif / fusion protein / TAT-WDM / KxKxx motif / COPII vesicle / DD sorting motif

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