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Structure paper

TitleStructure of a modular polyketide synthase reducing region.
Journal, issue, pagesStructure, Vol. 31, Page 1109-1120.e3, Year 2023
Publish dateFeb 17, 2023 (structure data deposition date)
AuthorsMcCullough, T.M. / Dhar, A. / Akey, D.L. / Konwerski, J.R. / Sherman, D.H. / Smith, J.L.
External linksStructure / PubMed:37348494
MethodsX-ray diffraction
Resolution1.815 - 3.4 Å
Structure data

PDB-8g7w:
Type I modPKS reducing region
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-8g7x:
Human fatty acid synthase dehydratase domain
Method: X-RAY DIFFRACTION / Resolution: 1.815 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SCN:
THIOCYANATE ION

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-ACT:
ACETATE ION

Source
  • micromonospora chalcea subsp. izumensis (bacteria)
  • homo sapiens (human)
KeywordsBIOSYNTHETIC PROTEIN / Polyketide synthase / reducing region / modPKS / LYASE / Human / fatty acid synthase / dehydratase

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