EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M.
ジャーナル・号・ページ	Nat Commun, Vol. 14, Issue 1, Page 2650, Year 2023
掲載日	2023年5月8日
著者	Chenggong Ji / Hao Shen / Chen Su / Yaxin Li / Shihua Chen / Thomas H Sharp / Junyu Xiao /
PubMed 要旨	Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to ...Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to facilitate P. falciparum clearance. A number of P. falciparum proteins bind IgM, leading to immune evasion and severe disease. However, the underlying molecular mechanisms remain unknown. Here, using high-resolution cryo-electron microscopy, we delineate how P. falciparum proteins VAR2CSA, TM284VAR1, DBLMSP, and DBLMSP2 target IgM. Each protein binds IgM in a different manner, and together they present a variety of Duffy-binding-like domain-IgM interaction modes. We further show that these proteins interfere directly with IgM-mediated complement activation in vitro, with VAR2CSA exhibiting the most potent inhibitory effect. These results underscore the importance of IgM for human adaptation of P. falciparum and provide critical insights into its immune evasion mechanism.
リンク	Nat Commun / PubMed:37156765 / PubMed Central
手法	EM (単粒子)
解像度	3.18 - 3.71 Å
構造データ	33538 7y09 EMDB-33538, PDB-7y09: Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP 手法: EM (単粒子) / 解像度: 3.71 Å EMDB-33539: Cryo-EM local structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP 手法: EM (単粒子) / 解像度: 3.64 Å 33542 7y0h EMDB-33542, PDB-7y0h: Cryo-EM structure of human IgM-Fc in complex with the J chain and the P. falciparum VAR2CSA FCR3 手法: EM (単粒子) / 解像度: 3.56 Å 33547 7y0j EMDB-33547, PDB-7y0j: Cryo-EM structure of human IgM-Fc in complex with the J chain and the P. falciparum TM284VAR1 手法: EM (単粒子) / 解像度: 3.62 Å 33805 7yg2 EMDB-33805, PDB-7yg2: Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP2 手法: EM (単粒子) / 解像度: 3.32 Å EMDB-33806: Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP2 手法: EM (単粒子) / 解像度: 3.18 Å
化合物	ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン
由来	plasmodium falciparum (マラリア病原虫) homo sapiens (ヒト)
キーワード	IMMUNE SYSTEM / malaria / immunoglobin / Complex / antibody