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-Structure paper
タイトル | Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 66, Page 6122-6148, Year 2023 |
掲載日 | 2023年2月8日 (構造データの登録日) |
![]() | Romanov-Michailidis, F. / Hsiao, C.C. / Urner, L.M. / Jerhaoui, S. / Surkyn, M. / Miller, B. / Vos, A. / Dominguez Blanco, M. / Bueters, R. / Vinken, P. ...Romanov-Michailidis, F. / Hsiao, C.C. / Urner, L.M. / Jerhaoui, S. / Surkyn, M. / Miller, B. / Vos, A. / Dominguez Blanco, M. / Bueters, R. / Vinken, P. / Bekkers, M. / Walker, D. / Pietrak, B. / Eyckmans, W. / Dores-Sousa, J.L. / Joo Koo, S. / Lento, W. / Bauser, M. / Philippar, U. / Rombouts, F.J.R. |
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手法 | X線回折 |
解像度 | 1.4 - 1.94 Å |
構造データ | ![]() PDB-8g3s: ![]() PDB-8g3t: ![]() PDB-8g3u: ![]() PDB-8g3w: ![]() PDB-8g3x: ![]() PDB-8g3y: |
化合物 | ![]() ChemComp-FMT: ![]() ChemComp-YLT: ![]() ChemComp-HOH: ![]() ChemComp-EDO: ![]() ChemComp-YLK: ![]() ChemComp-YKT: ![]() ChemComp-PEG: ![]() ChemComp-YKX: ![]() ChemComp-YLF: ![]() ChemComp-CL: ![]() ChemComp-YKL: |
由来 |
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![]() | APOPTOSIS / Myeloid cell leukemia 1 / Mcl-1 / B-cell lymphoma 2 / Bcl-2 / BH3 mimetic / Protein-protein interaction / Modulator / Cancer / Leukemia / Myeloma / Lymphoma / Physicochemical properties / ADME properties / Cardiotoxicity / Therapeutic window |