Entry Database : PDB / ID : 8g3x Structure visualization Downloads & linksTitle MBP-Mcl1 in complex with ligand 32 ComponentsMaltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera Details Keywords APOPTOSIS / Myeloid cell leukemia 1 / Mcl-1 / B-cell lymphoma 2 / Bcl-2 / BH3 mimetic / Protein-protein interaction / Modulator / Cancer / Leukemia / Myeloma / Lymphoma / Physicochemical properties / ADME properties / Cardiotoxicity / Therapeutic windowFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cell fate determination / cellular homeostasis / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH domain binding / BH3 domain binding / negative regulation of anoikis / carbohydrate transmembrane transporter activity ... positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cell fate determination / cellular homeostasis / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH domain binding / BH3 domain binding / negative regulation of anoikis / carbohydrate transmembrane transporter activity / protein transmembrane transporter activity / maltose binding / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / maltose transport / maltodextrin transmembrane transport / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / intrinsic apoptotic signaling pathway in response to DNA damage / Signaling by ALK fusions and activated point mutants / Interleukin-4 and Interleukin-13 signaling / regulation of apoptotic process / mitochondrial outer membrane / periplasmic space / positive regulation of apoptotic process / protein heterodimerization activity / DNA damage response / negative regulation of apoptotic process / mitochondrion / nucleoplasm / membrane / nucleus / cytosol / cytoplasm Similarity search - Function Apoptosis regulator, Mcl-1 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 ... Apoptosis regulator, Mcl-1 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein / ACP-like superfamily / Carrier protein (CP) domain profile. / Phosphopantetheine binding ACP domain Similarity search - Domain/homology alpha-maltose / Chem-YLF / Maltodextrin-binding protein / Induced myeloid leukemia cell differentiation protein Mcl-1 Similarity search - ComponentBiological species Serratia sp. FS14 (bacteria)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.46 Å DetailsAuthors Miller, B.R. / Shaffer, P. Funding support 1items Details Hide detailsOrganization Grant number Country Other private
CitationJournal : J.Med.Chem. / Year : 2023Title : Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.Authors: Romanov-Michailidis, F. / Hsiao, C.C. / Urner, L.M. / Jerhaoui, S. / Surkyn, M. / Miller, B. / Vos, A. / Dominguez Blanco, M. / Bueters, R. / Vinken, P. / Bekkers, M. / Walker, D. / Pietrak, ... Authors : Romanov-Michailidis, F. / Hsiao, C.C. / Urner, L.M. / Jerhaoui, S. / Surkyn, M. / Miller, B. / Vos, A. / Dominguez Blanco, M. / Bueters, R. / Vinken, P. / Bekkers, M. / Walker, D. / Pietrak, B. / Eyckmans, W. / Dores-Sousa, J.L. / Joo Koo, S. / Lento, W. / Bauser, M. / Philippar, U. / Rombouts, F.J.R. History Deposition Feb 8, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 17, 2023 Provider : repository / Type : Initial releaseRevision 1.1 May 24, 2023 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID Revision 1.2 May 22, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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