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Structure paper

TitleMolecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein.
Journal, issue, pagesLife, Vol. 13, Year 2023
Publish dateJan 27, 2023 (structure data deposition date)
AuthorsAdolph, R.S. / Beck, E. / Schweimer, K. / Di Fonzo, A. / Weyand, M. / Rosch, P. / Wohrl, B.M. / Steegborn, C.
External linksLife / PubMed:37109478
MethodsX-ray diffraction
Resolution1.65 - 1.95 Å
Structure data

PDB-8ccw:
Crystal structure of human Sirt3 in complex with an acetylated HIV1 Tat-46-54 substrate peptide
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-8ccz:
Crystal structure of human Sirt3 in complex with an inhibiting HIV1 Tat-37-59 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsSIGNALING PROTEIN / Sirtuin / substrate / HIV / Tat / complex / inhibitor

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