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TitleBile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.
Journal, issue, pagesNat Microbiol, Vol. 8, Page 611-628, Year 2023
Publish dateNov 19, 2021 (structure data deposition date)
AuthorsFoley, M.H. / Walker, M.E. / Stewart, A.K. / O'Flaherty, S. / Gentry, E.C. / Patel, S. / Beaty, V.V. / Allen, G. / Pan, M. / Simpson, J.B. ...Foley, M.H. / Walker, M.E. / Stewart, A.K. / O'Flaherty, S. / Gentry, E.C. / Patel, S. / Beaty, V.V. / Allen, G. / Pan, M. / Simpson, J.B. / Perkins, C. / Vanhoy, M.E. / Dougherty, M.K. / McGill, S.K. / Gulati, A.S. / Dorrestein, P.C. / Baker, E.S. / Redinbo, M.R. / Barrangou, R. / Theriot, C.M.
External linksNat Microbiol / PubMed:36914755
MethodsX-ray diffraction
Resolution1.35 - 2.15 Å
Structure data

PDB-7sve:
Bile Salt Hydrolase A from Lactobacillus acidophilus
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-7svf:
Bile salt hydrolase A from Lactobacillus gasseri with taurine bound
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-7svg:
Bile Salt Hydrolase A from Lactobacillus gasseri with chenodeoxycholate and taurine bound
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

PDB-7svh:
Bile Salt Hydrolase B from Lactobacillus gasseri
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-7svi:
Bile Salt Hydrolase C from Lactobacillus johnsonii
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-7svj:
Bile Salt Hydrolase from Lactobacillus ingluviei
Method: X-RAY DIFFRACTION / Resolution: 1.43 Å

PDB-7svk:
Bile Salt Hydrolase from Lactobacillus reuteri
Method: X-RAY DIFFRACTION / Resolution: 1.66 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-TAU:
2-AMINOETHANESULFONIC ACID

ChemComp-K:
Unknown entry

ChemComp-JN3:
CHENODEOXYCHOLIC ACID

ChemComp-MG:
Unknown entry

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-CA:
Unknown entry

ChemComp-SO4:
SULFATE ION

Source
  • lactobacillus acidophilus (bacteria)
  • lactobacillus gasseri (bacteria)
  • lactobacillus johnsonii (bacteria)
  • lactobacillus ingluviei (bacteria)
  • lactobacillus reuteri (bacteria)
KeywordsHYDROLASE / bile salt hydrolase

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