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-Structure paper
Title | Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 4059-4085, Year 2023 |
Publish date | May 18, 2022 (structure data deposition date) |
![]() | Nishigaya, Y. / Takase, S. / Sumiya, T. / Kikuzato, K. / Sato, T. / Niwa, H. / Sato, S. / Nakata, A. / Sonoda, T. / Hashimoto, N. ...Nishigaya, Y. / Takase, S. / Sumiya, T. / Kikuzato, K. / Sato, T. / Niwa, H. / Sato, S. / Nakata, A. / Sonoda, T. / Hashimoto, N. / Namie, R. / Honma, T. / Umehara, T. / Shirouzu, M. / Koyama, H. / Yoshida, M. / Ito, A. / Shirai, F. |
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Methods | X-ray diffraction |
Resolution | 1.45 - 2 Å |
Structure data | ![]() PDB-7xua: ![]() PDB-7xub: ![]() PDB-7xuc: ![]() PDB-7xud: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-SFG: ![]() ChemComp-I5X: ![]() ChemComp-TRS: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-I6L: ![]() ChemComp-I6S: ![]() ChemComp-CL: ![]() ChemComp-I6Z: |
Source |
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![]() | TRANSFERASE / histone lysine methyltransferase / inhibitor / protein-inhibitor complex |