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Structure paper

TitleStructural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl-fluoride inhibitor of serine peptidases.
Journal, issue, pagesDalton Trans, Vol. 52, Page 3610-3622, Year 2023
Publish dateJan 30, 2023 (structure data deposition date)
AuthorsRodriguez-Banqueri, A. / Moliner-Culubret, M. / Mendes, S.R. / Guevara, T. / Eckhard, U. / Gomis-Ruth, F.X.
External linksDalton Trans / PubMed:36857690
MethodsX-ray diffraction
Resolution1.65 - 4.5 Å
Structure data

PDB-8cd8:
Ulilysin - C269A with AEBSF complex
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-8cdb:
Proulilysin E229A structure
Method: X-RAY DIFFRACTION / Resolution: 4.5 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-AES:
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE / protease inhibitor*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • methanosarcina acetivorans c2a (archaea)
  • escherichia coli (E. coli)
KeywordsHYDROLASE / Inhibitor / complex / protease / serine protease / metalloprotease / metzincin / Zymogen

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