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TitleMonobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation.
Journal, issue, pagesJ. Mol. Biol., Vol. 435, Page 168010-168010, Year 2023
Publish dateFeb 5, 2022 (structure data deposition date)
AuthorsSha, F. / Kurosawa, K. / Glasser, E. / Ketavarapu, G. / Albazzaz, S. / Koide, A. / Koide, S.
External linksJ. Mol. Biol. / PubMed:36806475
MethodsX-ray diffraction
Resolution2.39 Å
Structure data

PDB-7tvj:
Crystal Structure of Monobody Mb(SHP2PTP_13)/SHP2 PTP Domain Complex
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

Chemicals

ChemComp-FLC:
CITRATE ANION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsSIGNALING PROTEIN/IMMUNE SYSTEM / Monobody / SHP2 / Phosphatase / Complex / Inhibitor / Signaling / SIGNALING PROTEIN-IMMUNE SYSTEM complex

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