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TitleIsoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
Journal, issue, pagesNat Commun, Vol. 14, Page 635-635, Year 2023
Publish dateJun 30, 2022 (structure data deposition date)
AuthorsKordon, S.P. / Dutka, P. / Adamska, J.M. / Bandekar, S.J. / Leon, K. / Erramilli, S.K. / Adams, B. / Li, J. / Kossiakoff, A.A. / Arac, D.
External linksNat Commun / PubMed:36746957
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-8djg:
ADGRL3-lectin domain in complex with an activating synthetic antibody fragment
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/Immune System / adhesion GPCR / lectin domain / sAB / SIGNALING PROTEIN / SIGNALING PROTEIN-Immune System complex

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