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TitleThe Bacteriophage-Phage-Inducible Chromosomal Island Arms Race Designs an Interkingdom Inhibitor of dUTPases.
Journal, issue, pagesMicrobiol Spectr, Vol. 11, Page e0323222-e0323222, Year 2023
Publish dateOct 6, 2021 (structure data deposition date)
AuthorsSanz-Frasquet, C. / Ciges-Tomas, J.R. / Alite, C. / Penades, J.R. / Marina, A.
External linksMicrobiol Spectr / PubMed:36622213
MethodsX-ray diffraction
Resolution1.944 - 2.75 Å
Structure data

PDB-7pwj:
dUTPase from human in complex with Stl
Method: X-RAY DIFFRACTION / Resolution: 1.944 Å

PDB-7pwx:
dUTPase from M. tuberculosis in complex with Stl
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • staphylococcus aureus (bacteria)
  • homo sapiens (human)
  • mycobacterium tuberculosis h37rv (bacteria)
KeywordsSTRUCTURAL PROTEIN / dUTPase / dUTP / human / DNA / Mycobacterium tuberculosis

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