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TitleCrystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.
Journal, issue, pagesNucleic Acids Res., Vol. 51, Page 475-487, Year 2023
Publish dateDec 8, 2021 (structure data deposition date)
AuthorsImprachim, N. / Yosaatmadja, Y. / Newman, J.A.
External linksNucleic Acids Res. / PubMed:36546776
MethodsX-ray diffraction
Resolution1.65 - 2.53 Å
Structure data

PDB-7qgi:
Crystal structure of SARS-CoV-2 NSP14 in the absence of NSP10
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-7qif:
Crystal structure of SARS-CoV-2 NSP14 in complex with 7MeGpppG.
Method: X-RAY DIFFRACTION / Resolution: 2.53 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-GTG:
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / Nuclease / Methyltransferase / SARS-CoV-2 / NSP14

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