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-Structure paper
Title | Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 16818-16828, Year 2022 |
Publish date | Oct 7, 2021 (structure data deposition date) |
![]() | Pallesen, J.S. / Munier, C.C. / Bosica, F. / Andrei, S.A. / Edman, K. / Gunnarsson, A. / La Sala, G. / Putra, O.D. / Srdanovic, S. / Wilson, A.J. ...Pallesen, J.S. / Munier, C.C. / Bosica, F. / Andrei, S.A. / Edman, K. / Gunnarsson, A. / La Sala, G. / Putra, O.D. / Srdanovic, S. / Wilson, A.J. / Wissler, L. / Ottmann, C. / Perry, M.W.D. / O'Mahony, G. |
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Methods | X-ray diffraction |
Resolution | 1.961 - 2.5 Å |
Structure data | ![]() PDB-7pwt: ![]() PDB-7pwz: ![]() PDB-8a9g: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-PJN: ![]() ChemComp-HOH: ![]() ChemComp-8CQ: ![]() ChemComp-BTB: ![]() ChemComp-QJK: |
Source |
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![]() | CHAPERONE / Nuclear receptor / phosphorylation / trafficking / PPI stabiliser / PROTEIN BINDING / 14-3-3 protein zeta/delta / Glucocorticoid Receptor / (R)-para chloropyrrolidone1 / protein-peptide complex / protein-protein interaction / PPI stabilisation / molecular glue / pyrrolidone1 analogue |