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TitleA marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation.
Journal, issue, pagesNat Commun, Vol. 13, Page 7262-7262, Year 2022
Publish dateJul 3, 2021 (structure data deposition date)
AuthorsWatari, H. / Kageyama, H. / Masubuchi, N. / Nakajima, H. / Onodera, K. / Focia, P.J. / Oshiro, T. / Matsui, T. / Kodera, Y. / Ogawa, T. ...Watari, H. / Kageyama, H. / Masubuchi, N. / Nakajima, H. / Onodera, K. / Focia, P.J. / Oshiro, T. / Matsui, T. / Kodera, Y. / Ogawa, T. / Yokoyama, T. / Hirayama, M. / Hori, K. / Freymann, D.M. / Imai, M. / Komatsu, N. / Araki, M. / Tanaka, Y. / Sakai, R.
External linksNat Commun / PubMed:36433967
MethodsX-ray diffraction
Resolution1.1 - 1.419 Å
Structure data

PDB-7f91:
SeMet derivative of Thrombocorticin
Method: X-RAY DIFFRACTION / Resolution: 1.401 Å

PDB-7f9f:
Thrombocorticin
Method: X-RAY DIFFRACTION / Resolution: 1.411 Å

PDB-7f9g:
Thrombocorticin in complex with Ca2+ and fucose
Method: X-RAY DIFFRACTION / Resolution: 1.331 Å

PDB-7f9j:
Thrombocorticin Q25K in complex with Ca2+
Method: X-RAY DIFFRACTION / Resolution: 1.1 Å

PDB-7fbl:
Thrombocorticin in complex with Ca2+ and mannose
Method: X-RAY DIFFRACTION / Resolution: 1.419 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-CA:
Unknown entry

ChemComp-MAN:
alpha-D-mannopyranose

Source
  • corticium sp. (in: fungi) (fungus)
KeywordsSUGAR BINDING PROTEIN / bioactive protein / Thrombocorticin

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