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Title | Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 245, Page 114914-114914, Year 2023 |
Publish date | Nov 18, 2021 (structure data deposition date) |
![]() | Heyder, L. / Hochban, P.M.M. / Taylor, C. / Chevillard, F. / Siefker, C. / Iking, C. / Borchardt, H. / Aigner, A. / Klebe, G. / Heine, A. ...Heyder, L. / Hochban, P.M.M. / Taylor, C. / Chevillard, F. / Siefker, C. / Iking, C. / Borchardt, H. / Aigner, A. / Klebe, G. / Heine, A. / Kolb, P. / Diederich, W.E. |
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Methods | X-ray diffraction |
Resolution | 1.95 - 2.53 Å |
Structure data | ![]() PDB-7qb2: ![]() PDB-7qfm: ![]() PDB-7z6u: ![]() PDB-8afr: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-A7X: ![]() ChemComp-HOH: ![]() ChemComp-AY3: ![]() ChemComp-IJB: ![]() ChemComp-M0F: |
Source |
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![]() | TRANSFERASE / SERINE KINASE / KINASE / COMPLEX / PIM1 / PIM / PIM-1 / INHIBITOR / TUMORIGENISIS / CANCER / PIMTIDE / PROTO ONCOGEN / ATP / PHOSPHORYLATION / APOPTOSIS / CELL CYCLE |