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Structure paper

TitleA genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages.
Journal, issue, pagesNat Commun, Vol. 13, Page 6562-6562, Year 2022
Publish dateNov 17, 2021 (structure data deposition date)
AuthorsSun, P. / Zhang, Z. / Wang, B. / Liu, C. / Chen, C. / Liu, P. / Li, X.
External linksNat Commun / PubMed:36333306
MethodsX-ray diffraction
Resolution1.48 - 3.25 Å
Structure data

PDB-7w06:
Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate (SeMet labeled), Space group C121.
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-7w07:
Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate, Space group C121.
Method: X-RAY DIFFRACTION / Resolution: 1.48 Å

PDB-7w08:
Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in APO form, Space group P1.
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

Chemicals

ChemComp-ITN:
2-methylidenebutanedioic acid

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • yersinia pseudotuberculosis serotype o:3 (strain ypiii) (bacteria)
KeywordsTRANSCRIPTION / LTTR / ITCR / itaconate

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