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Structure paper

TitleEpstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition.
Journal, issue, pagesImmunity, Vol. 55, Page 2135-2148.e6, Year 2022
Publish dateAug 30, 2021 (structure data deposition date)
AuthorsChen, W.H. / Kim, J. / Bu, W. / Board, N.L. / Tsybovsky, Y. / Wang, Y. / Hostal, A. / Andrews, S.F. / Gillespie, R.A. / Choe, M. ...Chen, W.H. / Kim, J. / Bu, W. / Board, N.L. / Tsybovsky, Y. / Wang, Y. / Hostal, A. / Andrews, S.F. / Gillespie, R.A. / Choe, M. / Stephens, T. / Yang, E.S. / Pegu, A. / Peterson, C.E. / Fisher, B.E. / Mascola, J.R. / Pittaluga, S. / McDermott, A.B. / Kanekiyo, M. / Joyce, M.G. / Cohen, J.I.
External linksImmunity / PubMed:36306784
MethodsX-ray diffraction
Resolution2.15 - 3.29 Å
Structure data

PDB-7s07:
Crystal structure of Epstein-Barr virus glycoprotein gH/gL/gp42-peptide in complex with human neutralizing antibodies 769B10 and 769C2
Method: X-RAY DIFFRACTION / Resolution: 3.29 Å

PDB-7s08:
Crystal structure of Epstein-Barr virus gH/gL targeting antibody 770F7
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

PDB-7s0j:
Crystal structure of Epstein-Barr virus gH/gL targeting antibody 769B10
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-7s1b:
Crystal structure of Epstein-Barr virus glycoproteins gH/gL/gp42-peptide in complex with human neutralizing antibodies 769C2 and 770F7
Method: X-RAY DIFFRACTION / Resolution: 3.03 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • human gammaherpesvirus 4 (Epstein-Barr virus)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM/VIRAL PROTEIN / Antibody / Fab / IMMUNE SYSTEM / gH/gL / Epstein-Barr virus / herpesvirus / IMMUNE SYSTEM-VIRAL PROTEIN complex

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