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-Structure paper
タイトル | Shape-Morphing of an Artificial Protein Cage with Unusual Geometry Induced by a Single Amino Acid Change. |
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ジャーナル・号・ページ | ACS Nanosci Au, Vol. 2, Issue 5, Page 404-413, Year 2022 |
掲載日 | 2022年10月19日 |
著者 | Mohit Sharma / Artur P Biela / Agnieszka Kowalczyk / Kinga Borzęcka-Solarz / Bernard M A G Piette / Szymon Gaweł / Joshua Bishop / Philipp Kukura / Justin L P Benesch / Motonori Imamura / Simon Scheuring / Jonathan G Heddle / |
PubMed 要旨 | Artificial protein cages are constructed from multiple protein subunits. The interaction between the subunits, notably the angle formed between them, controls the geometry of the resulting cage. ...Artificial protein cages are constructed from multiple protein subunits. The interaction between the subunits, notably the angle formed between them, controls the geometry of the resulting cage. Here, using the artificial protein cage, "TRAP-cage", we show that a simple alteration in the position of a single amino acid responsible for Au(I)-mediated subunit-subunit interactions in the constituent ring-shaped building blocks results in a more acute dihedral angle between them. In turn, this causes a dramatic shift in the structure from a 24-ring cage with an octahedral symmetry to a 20-ring cage with a C2 symmetry. This symmetry change is accompanied by a decrease in the number of Au(I)-mediated bonds between cysteines and a concomitant change in biophysical properties of the cage. |
リンク | ACS Nanosci Au / PubMed:36281256 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 9.13 Å |
構造データ | EMDB-13924: Shape-morphing of an artificial protein cage with unusual geometry induced by a single amino acid change |
由来 |
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